Changes in glutamate receptors, c-fos mRNA expression and activator protein-1 (AP-1) DNA binding activity in the brain of phenobarbital-dependent and-withdrawn …
S Tanaka, Y Kiuchi, S Numazawa, K Oguchi, T Yoshida… - Brain research, 1997 - Elsevier
We studied changes in glutamate receptors, expression of immediate early genes, and AP-1
DNA binding activity in the brains of phenobarbital (PB)-dependent and-withdrawn rats to
investigate the possible involvement of activation of glutamate receptors in PB withdrawal
syndrome. PB-dependent rats were prepared by feeding drug-admixed food for 5 weeks.
Autoradiographic analysis showed that binding of [3H](+)-5-methyl-10, 11-dihydro-5H-
dibenzo [a, d] cyclohepten-5, 10-imine (MK-801), an antagonist of N-methyl-d-aspartic acid …
DNA binding activity in the brains of phenobarbital (PB)-dependent and-withdrawn rats to
investigate the possible involvement of activation of glutamate receptors in PB withdrawal
syndrome. PB-dependent rats were prepared by feeding drug-admixed food for 5 weeks.
Autoradiographic analysis showed that binding of [3H](+)-5-methyl-10, 11-dihydro-5H-
dibenzo [a, d] cyclohepten-5, 10-imine (MK-801), an antagonist of N-methyl-d-aspartic acid …
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